Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations
Alzheimer's disease-related mutations in the presenilin-1 gene (PS1) are leading to an elevated production of neurotoxic beta-amyloid 1-42 and may additionally enhance oxidative stress. Here, we provide in vivo evidence indicating that brains of transgenic mice expressing different human Alzheimer-linked PS1 mutations exhibit a reduced activity of two antioxidant enzymes. For this purpose, mice transgenic for human PS1 and for single and multiple PS1 mutations were generated. Mice with multiple PS1 mutations showed a significantly decreased activity of the antioxidant enzymes Cu/Zn superoxide dismutase and glutathione reductase already at an age of 3-4 months. As expected, this effect was less pronounced for the mice with a single PS1 mutation. By contrast, animals bearing normal human PS1 showed significantly elevated enzyme activities relative to non-transgenic littermate controls.
| Author: | Silke Leutner, Christian Czech, Katharina Schindowski, Nathalie Touchet, Anne Eckert, Walter E. Müller |
|---|---|
| URN: | urn:nbn:de:hebis:30-34419 |
| Parent Title (English): | Neuroscience letters : an international multidisciplinary journal devoted to the rapid publication of basic research in the neurosciences |
| Publisher: | Elsevier Science |
| Place of publication: | Amsterdam [u.a.] |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 06.12.2006 |
| Year of first Publication: | 2000 |
| Publishing Institution: | Univ.-Bibliothek Frankfurt am Main |
| Tag: | Alzheimer's disease ; Glutathione reductase ; Lipid peroxidation; Presenilin ; Reactive oxygen species ; Superoxide dismutase |
| Volume: | 292 |
| Issue: | 2, Oct. 6 |
| Pagenumber: | 4 |
| First Page: | 87 |
| Last Page: | 90 |
| HeBIS PPN: | 288691466 |
| Institutes: | Pharmazie |
| Dewey Decimal Classification: | 570 Biowissenschaften; Biologie |
| Sammlungen: | Universitätspublikationen |
| Sondersammelgebiets-Volltexte Biologie | |
| Licence (German): |  Veröffentlichungsvertrag für Publikationen ohne Print on Demand |
