Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations

Alzheimer's disease-related mutations in the presenilin-1 gene (PS1) are leading to an elevated production of neurotoxic beta-amyloid 1-42 and may additionally enhance oxidative stress. Here, we provide in vivo evidence 
Alzheimer's disease-related mutations in the presenilin-1 gene (PS1) are leading to an elevated production of neurotoxic beta-amyloid 1-42 and may additionally enhance oxidative stress. Here, we provide in vivo evidence indicating that brains of transgenic mice expressing different human Alzheimer-linked PS1 mutations exhibit a reduced activity of two antioxidant enzymes. For this purpose, mice transgenic for human PS1 and for single and multiple PS1 mutations were generated. Mice with multiple PS1 mutations showed a significantly decreased activity of the antioxidant enzymes Cu/Zn superoxide dismutase and glutathione reductase already at an age of 3-4 months. As expected, this effect was less pronounced for the mice with a single PS1 mutation. By contrast, animals bearing normal human PS1 showed significantly elevated enzyme activities relative to non-transgenic littermate controls.
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Metadaten
Author:Silke Leutner, Christian Czech, Katharina Schindowski, Nathalie Touchet, Anne Eckert, Walter E. Müller
URN:urn:nbn:de:hebis:30-34419
Parent Title (English):Neuroscience letters : an international multidisciplinary journal devoted to the rapid publication of basic research in the neurosciences
Publisher:Elsevier Science
Place of publication:Amsterdam [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2006/12/06
Year of first Publication:2000
Publishing Institution:Univ.-Bibliothek Frankfurt am Main
Release Date:2006/12/06
Tag:Alzheimer's disease ; Glutathione reductase ; Lipid peroxidation; Presenilin ; Reactive oxygen species ; Superoxide dismutase
Volume:292
Issue:2, Oct. 6
Pagenumber:4
First Page:87
Last Page:90
HeBIS PPN:288691466
Institutes:Pharmazie
Dewey Decimal Classification:570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Sondersammelgebiets-Volltexte
Licence (German):License Logo Veröffentlichungsvertrag für Publikationen

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