Biological activities of aqueous and organic extracts from tropical marine sponges

We report on screening tests of 66 extracts obtained from 35 marine sponge species from the Caribbean Sea (Curaçao) and from eight species from the Great Barrier Reef (Lizard Island). Extracts were prepared in aqueous an
We report on screening tests of 66 extracts obtained from 35 marine sponge species from the Caribbean Sea (Curaçao) and from eight species from the Great Barrier Reef (Lizard Island). Extracts were prepared in aqueous and organic solvents and were tested for hemolytic, hemagglutinating, antibacterial and anti-acetylcholinesterase (AChE) activities, as well as their ability to inhibit or activate cell protein phosphatase 1 (PP1). The most interesting activities were obtained from extracts of Ircinia felix, Pandaros acanthifolium, Topsentia ophiraphidites, Verongula rigida and Neofibularia nolitangere. Aqueous and organic extracts of I. felix and V. rigida showed strong antibacterial activity. Topsentia aqueous and some organic extracts were strongly hemolytic, as were all organic extracts from I. felix. The strongest hemolytic activity was observed in aqueous extracts from P. acanthifolium. Organic extracts of N. nolitangere and I. felix inhibited PP1. The aqueous extract from Myrmekioderma styx possessed the strongest hemagglutinating activity, whilst AChE inhibiting activity was found only in a few sponges and was generally weak, except in the methanolic extract of T. ophiraphidites.
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Metadaten
Author:Kristina Sepčić, Silke Kauferstein, Dietrich Mebs, Tom Turk
URN:urn:nbn:de:hebis:30:3-253105
DOI:http://dx.doi.org/10.3390/md8051550
ISSN:1660-3397
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=20559488
Parent Title (English):Marine drugs
Publisher:Molecular Diversity Preservation International (MDPI)
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2010/04/28
Date of first Publication:2010/04/28
Publishing Institution:Univ.-Bibliothek Frankfurt am Main
Release Date:2012/06/27
Tag:acetylcholinesterase (AChE) inhibition; antibacterial activity; hemagglutination; hemolysis; protein phosphatase 1 (PP1) inhibition/activation; tropical marine sponges
Volume:8.2010
Issue:5
Pagenumber:17
First Page:1550
Last Page:1566
Institutes:Medizin
Dewey Decimal Classification:570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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