Specific immunotherapy in Albanian patients with anaphylaxis to hymenoptera venoms

BACKGROUND: Severe allergic reactions during rush-specific immunotherapy (Rush-SIT) may occur in the treatment of hymenoptera sting allergy. The objective of the present study was to examine the characteristics of allerg
BACKGROUND: Severe allergic reactions during rush-specific immunotherapy (Rush-SIT) may occur in the treatment of hymenoptera sting allergy. The objective of the present study was to examine the characteristics of allergic reactions during Rush-SIT in a cohort of patients with allergy towards hymenoptera venom in the mediterranean population of Albania.

METHODS: A retrospective study was performed using the clinical reports of 37 patients with venom of bee (apinae), wasp (vespidae, subfamily vespinae) or paperwasp (vespidae, subfamily polistinae) allergy treated with Rush-SIT between 1987 and 1996. After hymenoptera sting allergy diagnosis according to anamnesis and intracutaneous tests the patient were treated with Rush-SIT. The protocol lasted 3 - 4 d with an increase in the concentration from 0.01 microg/ml to 100 microg/ml. Anaphylactic reactions were classified according to the Mueller-classification.

RESULTS: The frequency of reactions during Rush-SIT for bee-venom was 4.7% and for wasp-venom was 1.5% (p < 0.01). The mean frequency of reactions of Mueller grade II for the bee-venom Rush-SIT patients during the first 4 d (= 26 injections) was 0.73 and for the wasp-venom Rush-SIT patients 0.15. No patient experienced a third-degree reaction. 94.6% of the patient supported an end dose of 100 microg.

CONCLUSIONS: Rush-SIT is a reliable method for the treatment of anaphylactic reactions to hymenoptera venom even in less developed countries. Bee-venom Rush-SIT was found to cause higher numbers allergic reactions than wasp or paperwasp Rush-SIT.
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Metadaten
Author:Ervin Mingomataj, Alfred Priftanji, Etleva Qirko, Q Thai Dinh, Axel Fischer, Christian Peiser, Jan David Alexander Groneberg
URN:urn:nbn:de:hebis:30:3-258070
DOI:http://dx.doi.org/10.1186/1471-5945-2-11
ISSN:1471-5945
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=12201901
Parent Title (English):BMC dermatology
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Language:English
Date of Publication (online):2002/08/30
Date of first Publication:2002/08/30
Publishing Institution:Univ.-Bibliothek Frankfurt am Main
Release Date:2012/08/31
Tag:Rush; Rush-SIT; anaphylactic reactions; hymenoptera
Volume:2
Issue:2:11
Pagenumber:6
First Page:1
Last Page:6
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0

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