Latest documents http://publikationen.stub.uni-frankfurt.de/index/index/ Fri, 22 Mar 2013 15:52:13 +0100 Fri, 22 Mar 2013 15:52:13 +0100 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/29273 Balloon-borne measurements of CFC-11 (on flights of the DIRAC in situ gas chromatograph and the DESCARTES grab sampler), ClO and O3 were made during the 1999/2000 winter as part of the SOLVE-THESEO 2000 campaign. Here we present the CFC-11 data from nine flights and compare them first with data from other instruments which flew during the campaign and then with the vertical distributions calculated by the SLIMCAT 3-D CTM. We calculate ozone loss inside the Arctic vortex between late January and early March using the relation between CFC-11 and O3 measured on the flights, the peak ozone loss (1200 ppbv) occurs in the 440–470 K region in early March in reasonable agreement with other published empirical estimates. There is also a good agreement between ozone losses derived from three independent balloon tracer data sets used here. The magnitude and vertical distribution of the loss derived from the measurements is in good agreement with the loss calculated from SLIMCAT over Kiruna for the same days. Alan D. Robinson; Genevieve A. Millard; François Danis; Marielle Guirlet Neil R. P. Harris; Adrian M. Lee; J. D. McIntyre; John A. Pyle; Johan Arvelius; S. Dagnesjo; Sheila Kirkwood; Hampus Nilsson; Darin W. Toohey; Terry Deshler; Florence Goutail; Jean-Pierre Pommereau; James W. Elkins; Fred L. Moore; Eric Ray; Ulrich Schmidt; Andreas Engel; Melanie Müller article http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/29273 Fri, 22 Mar 2013 15:52:13 +0100 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/27360 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/27360 Mon, 05 Nov 2012 13:52:50 +0100 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/26816 periodical http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/26816 Tue, 30 Oct 2012 10:38:59 +0100 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/25545 Chronic obstructive pulmonary disease (COPD) is a major global health problem and is predicted to become the third most common cause of death by 2020. Apart from the important preventive steps of smoking cessation, there are no other specific treatments for COPD that are as effective in reversing the condition, and therefore there is a need to understand the pathophysiological mechanisms that could lead to new therapeutic strategies. The development of experimental models will help to dissect these mechanisms at the cellular and molecular level. COPD is a disease characterized by progressive airflow obstruction of the peripheral airways, associated with lung inflammation, emphysema and mucus hypersecretion. Different approaches to mimic COPD have been developed but are limited in comparison to models of allergic asthma. COPD models usually do not mimic the major features of human COPD and are commonly based on the induction of COPD-like lesions in the lungs and airways using noxious inhalants such as tobacco smoke, nitrogen dioxide, or sulfur dioxide. Depending on the duration and intensity of exposure, these noxious stimuli induce signs of chronic inflammation and airway remodelling. Emphysema can be achieved by combining such exposure with instillation of tissue-degrading enzymes. Other approaches are based on genetically-targeted mice which develop COPD-like lesions with emphysema, and such mice provide deep insights into pathophysiological mechanisms. Future approaches should aim to mimic irreversible airflow obstruction, associated with cough and sputum production, with the possibility of inducing exacerbations. Jan David Alexander Groneberg; K Fan Chung article http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/25545 Fri, 24 Aug 2012 14:45:45 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/25267 Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia. Their structures were established as (R)-1-hydroxymethyl-7-8-dimethoxy-1,2,3,4-tetrahydro- isoquinoline (1) and (S)-7-hydroxymethyl-2-3-dimethoxy-7,8,9,10-tetrahydroisoquinoline chloride (2) by spectroscopic techniques and X-ray diffraction analysis. Ali El Antri; Ibtissam Messouri; Mohamed Bouktaib; Rachid El Alami; Michael Bolte; Brahim El Bali; Mohammed Lachkar article http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/25267 Wed, 27 Jun 2012 14:01:17 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/25252 We have used the SLIMCAT 3-D off-line chemical transport model (CTM) to quantify the Arctic chemical ozone loss in the year 2002/2003 and compare it with similar calculations for the winters 1999/2000 and 2003/2004. Recent changes to the CTM have improved the model's ability to reproduce polar chemical and dynamical processes. The updated CTM uses σ-θ as a vertical coordinate which allows it to extend down to the surface. The CTM has a detailed stratospheric chemistry scheme and now includes a simple NAT-based denitrification scheme in the stratosphere. In the model runs presented here the model was forced by ECMWF ERA40 and operational analyses. The model used 24 levels extending from the surface to ~55 km and a horizontal resolution of either 7.5°×7.5° or 2.8°×2.8°. Two different radiation schemes, MIDRAD and the CCM scheme, were used to diagnose the vertical motion in the stratosphere. Based on tracer observations from balloons and aircraft, the more sophisticated CCM scheme gives a better representation of the vertical transport in this model which includes the troposphere. The higher resolution model generally produces larger chemical O3 depletion, which agrees better with observations. The CTM results show that very early chemical ozone loss occurred in December 2002 due to extremely low temperatures and early chlorine activation in the lower stratosphere. Thus, chemical loss in this winter started earlier than in the other two winters studied here. In 2002/2003 the local polar ozone loss in the lower stratosphere was ~40% before the stratospheric final warming. Larger ozone loss occurred in the cold year 1999/2000 which had a persistently cold and stable vortex during most of the winter. For this winter the current model, at a resolution of 2.8°×2.8°, can reproduce the observed loss of over 70% locally. In the warm and more disturbed winter 2003/2004 the chemical O3 loss was generally much smaller, except above 620 K where large losses occurred due to a period of very low minimum temperatures at these altitudes. Wuhu Feng; Martyn P. Chipperfield; Stewart Davies; Bhaswar Sen; Geoffrey C. Toon; Jean-François Blavier; Christopher R. Webster; C.-Michael Volk; Alexey Ulanovsky; Fabrizio Ravegnani; Peter von der Gathen; Hans-Jürg Jost; Erik C. Richard; Hans Claude article http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/25252 Mon, 18 Jun 2012 17:20:25 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/24980 conferenceobject http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/24980 Wed, 23 May 2012 14:33:46 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/22074 Olga Ramírez Calle doctoralthesis http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/22074 Wed, 20 Jul 2011 11:41:02 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21789 Conference Reader zur gemeinsam von Athansios Orphanides (Federal Reserve Board, Washington D.C.), John C. Williams (Federal Reserve Bank of San Francisco), Heinz Hermann (Deutsche Bundesbank), und Volker Wieland (Center for Financial Studies and Goethe University Frankfurt) organisierten Konferenz, die vom 30. - 31. August, 2003 in Eltville stattgefunden hat. Inhaltsverzeichnis: * Volker Wieland (Director Center for Financial Studies): Foreword * Hans Georg Fabritius (Member of the Executive Board of the Deutsche Bundesbank): Opening Remarks * Charles Goodhart (Norman Sosnow Professor of Banking and Finance at the London School of Economics and External Member of the Bank of England's Monetary Policy Commitee): After Dinner Speech * Paper Abstracts * List of Participants book http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21789 Wed, 08 Jun 2011 13:42:58 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21417 Schwerpunktthema: Physik periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21417 Mon, 16 May 2011 15:05:20 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21416 Schwerpunktthema: Körperinszenierungen periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21416 Mon, 16 May 2011 14:51:22 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21415 Schwerpunktthema: 150.Geburtstag Paul Ehrlich periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21415 Mon, 16 May 2011 14:44:09 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21397 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21397 Thu, 12 May 2011 12:31:03 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21387 other http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21387 Wed, 11 May 2011 13:58:54 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21374 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21374 Wed, 11 May 2011 13:13:39 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21292 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21292 Tue, 10 May 2011 15:34:12 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21290 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21290 Tue, 10 May 2011 14:33:25 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21261 periodical http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21261 Fri, 06 May 2011 15:20:50 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21250 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21250 Fri, 06 May 2011 14:30:08 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21209 other http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/21209 Fri, 06 May 2011 11:20:43 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10961 other http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10961 Fri, 06 May 2011 09:47:06 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10968 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10968 Fri, 06 May 2011 09:00:01 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10983 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10983 Thu, 05 May 2011 16:56:53 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10982 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10982 Thu, 05 May 2011 16:56:22 +0200 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10984 periodicalpart http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/10984 Thu, 05 May 2011 16:55:19 +0200