Latest documents http://publikationen.stub.uni-frankfurt.de/index/index/ Fri, 25 Jan 2013 09:24:47 +0100 Fri, 25 Jan 2013 09:24:47 +0100 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/28146 other http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/28146 Fri, 25 Jan 2013 09:24:47 +0100 http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/27776 The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation. The cascade of events leading to cell death or late effects starts from stochastic energy deposition on the nanometer scale and the corresponding lesions in biological molecules, primarily DNA. We have developed experimental techniques to visualize DNA nanolesions induced by heavy ions. Nanolesions appear in cells as “streaks” which can be visualized by using different DNA repair markers. We have studied the kinetics of repair of these “streaks” also with respect to the chromatin conformation. Initial steps in the modeling of the energy deposition patterns at the micrometer and nanometer scale were made with MCHIT and TRAX models, respectively. Marcus Bleicher; Lucas Burigo; Marco Durante; Maren Herrlitz; Michael Krämer; Igor Mishustin; Iris Müller; Francesco Natale; Igor Pshenichnov; Stefan Schramm; Gisela Taucher-Scholz; Cathrin Wälzlein article http://publikationen.stub.uni-frankfurt.de/frontdoor/index/index/docId/27776 Thu, 13 Dec 2012 16:28:23 +0100