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kurz und kn@pp news : Nr. 3 (2005)

* „Den Patienten im Blick behalten“ - Konferenz zum Thema Chronic Care in der Primärmedizin * Richard-Merten-Preis 2005 Fehlerberichts- und Lernsystem für Hausärzte ausgezeichnet * Ab 2006 Praktisches Jahr in allgemeinmedizinischen Lehrpraxen * Der Arbeitsbereich Lehre stellt sich vor * Neue Leitlinie Herzinsuffizienz: Machen Sie mit beim Praxistest! * Vermeidung von Medikationsfehlern in der Hausarztpraxis

kurz und kn@pp news : Nr. 1 (2005)

Erste Ausgabe des Instituts-Newsletters * Depression: Neue Strategien für Hausarztpraxis * Link des Monats: Jeder Fehler zählt * E-Learning: Aktueller Stand und Chancen * Neue Lehrpraxen für das Blockpraktikum Allgemeinmedizin * Qualitätsförderung und Patientensicherheit * Neues Hausarztmodell vereinbart

kurz und kn@pp news : Nr. 2 (2005)

* Antrittsvorlesung zog zahlreiche Zuhörer an * Fehlerberichtssystem mit dem Richard-Merten-Preis ausgezeichnet * Zentrum für Gesundheitswissenschaften gegründet * Die Zukunft ist chronisch... * PRoMPT-Projekt hat begonnen – Mehr als 70 Praxisteams geschult * Symposium E-Learning – Innovation für die medizinische Lehre

Protein C preserves microcirculation in a model of neonatal septic shock (2005)

Doris Fischer Marcel Friedrich Nold Claudia A. Nold-Petry Antonio Furlan Alex Veldman

Objectives: Sepsis remains a disease with a high mortality in neonates. Microcirculatory impairment plays a pivotal role in the development of multiorgan failure in septic newborns. The hemodynamic effects of recombinant activated protein C (rhAPC) were tested in an animal model of neonatal septic shock focusing on intestinal microcirculation. Materials and methods: Endotoxic shock was triggered by intravenous application of Escherichia coli lipopolysaccarides in newborn piglets. Thereafter, five animals received a continuous infusion of 24 µg/kg/h rhAPC, and five received vehicle for control. Over the course of three hours, intestinal microcirculation was assessed by intravital microscopy every 30 min. Macrocirculation and blood counts were monitored simultaneously. Results: After a short hypotensive period in all animals, the arterial blood pressure returned to baseline in the rhAPC-treated piglets, whereas the hypotension became increasingly severe in the controls. By 90 min, mean blood pressure in the controls was significantly lower than in the treatment group. Similar observations were made regaring microcirculation. After an early impairment in all study animals, functional capillary density and intestinal microcirculatory red blood cell velocity and red blood cell flow recovered in the rhAPC group, but deteriorated further in the control piglets. Conclusion: Recombinant activated protein C protects macro- and microcirculation from endotoxic shock.

Molecular mechanisms of severe acute respiratory syndrome (SARS) (2005)

Jan David Alexander Groneberg Rolf Hilgenfeld Peter Zabel

Severe acute respiratory syndrome (SARS) is a new infectious disease caused by a novel coronavirus that leads to deleterious pulmonary pathological features. Due to its high morbidity and mortality and widespread occurrence, SARS has evolved as an important respiratory disease which may be encountered everywhere in the world. The virus was identified as the causative agent of SARS due to the efforts of a WHO-led laboratory network. The potential mutability of the SARS-CoV genome may lead to new SARS outbreaks and several regions of the viral genomes open reading frames have been identified which may contribute to the severe virulence of the virus. With regard to the pathogenesis of SARS, several mechanisms involving both direct effects on target cells and indirect effects via the immune system may exist. Vaccination would offer the most attractive approach to prevent new epidemics of SARS, but the development of vaccines is difficult due to missing data on the role of immune system-virus interactions and the potential mutability of the virus. Even in a situation of no new infections, SARS remains a major health hazard, as new epidemics may arise. Therefore, further experimental and clinical research is required to control the disease. Keywords: Severe Acute Respiratory Syndrome; SARS; coronavirus; molecular mechanisms; therapy; vaccination

Jahresbericht 2002 / Fachbereich Medizin und Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main (2005)

Jahresbericht 2004 / Fachbereich Medizin und Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main (2005)

Newsletter / Frankfurter Klinikallianz. Nr. 3, 2005 (2005)

Newsletter / Frankfurter Klinikallianz. Nr. 2, 2005 (2005)

Newsletter / Frankfurter Klinikallianz. Nr. 1, 2005 (2005)

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