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“Too close to call” : CNN's politics of captions in the coverage of the Florida Recount
(2003)
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Raimund Schieß
- Proceeding chronologically in terms of the events covered, Raimund Schieß in his paper „Too close to call: CNN’s politics of captions in the coverage of the Florida Recount“ focusses on Nov. 11, 2000, when the Bush campaign applied to Miami Federal Court to stop the manual recount of ballots which had been started in some counties. The paper studies the discursive practices employed by the CNN journalists to construct a particular version of the events, focussing on captions, i.e. the lines of text inserted at the bottom of the tv screen, and on the way in which they interact with the other verbal and visual components of the television text. Raimund Schieß concludes that captions, far beyond providing mere details of a speech event (who is talking to whom about what, where and when), are used to select, to highlight and hide, and thus to invite a preferred interpretation of the event. He is also able to show that captions are often employed to exploit a story’s potential for drama and sensation. His detailed micro-analysis of the verbal and visual dimensions of the television text is supported by careful documentation of the data, either through screen shots or via transcriptions of the stretches of broadcast discussed.
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“It was not Death” : The Poetic Career of the Chronotope
(2010)
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Joy Ladin
- As Bakhtin noted, chronotopes arise from the density and fusion of temporal and spatial indicators. In prose narrative, the density of temporal and spatial indicators arises as a natural consequence of setting scenes and explaining action, and those indicators are fused by the centripetal forces of plot, character and so on that encourage us to read the various elements of the text as aspects of a coherent story and world. In non-narrative poetry, however, there is no story to drive the setting of scene or generation of character; there may not even be scene or character. As a result, temporal and spatial indicators can be quite sparse, and there may be little centripetal force to encourage their fusion. In a textual environment bereft of character, plot, scene, in which even the centripetal forces of syntax are frayed by linebreaks and other poetic devices, how can chronotopes form and function? [...] In the centripetal environment afforded by most prose narratives, the stable chronotopes and the relationships among them define consciousness, world and values. In the centrifugal environment of non-narrative poetry, chronotopes flicker and flow in a series of hints, glimpses, dissolves, defining consciousness, world and values via evanescence rather than stability. However, as I hope to show below, the evanescence of chronotopes in non-narrative poetry can be as central to the vitality and meaning of those texts as the stability of chronotopes is to the vitality and meaning of prose narratives.
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‘Turning many to righteousness’ : Religious didacticism in the ›Speculum humanae salvationis‹ and the similitude of the oak tree
(2009)
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Nigel F. Palmer
- In this contribution I shall be interested, among other things, in finding a place for the European phenomenon of the ›Speculum humanae salvationis‹ within German literary history, which will inescapably involve revisiting the unfashionable discussion of date and origins. I also intend to ask about the place of this text in the ‘didactic’ literature of the Middle Ages. Is a religious text structured according to sacred history didactic? Much didactic poetry is in the vernacular: What does it mean that the ›Speculum‹ was composed in Latin? And what place should be accorded to its vernacular reception? The ›Speculum‹ is inscribed within a set of oppositions that would appear to be recurrent in the didactic literature of the later Middle Ages: Latin and vernacular, verse and prose, words and pictures, religious and profane, moral
teaching and devotion, clerical and lay. In view of its exceptionally broad transmission in the German lands, both in Latin and in vernacular reworkings, is it possible to describe this text so that it takes a place within a larger picture? In some respects it may stand at a threshold in the history of European didacticism.
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Über quasistationäre Verteilungen
(1997)
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Lars Kauffmann
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ß-amyloid-mediated mitochondria-dependent cell death pathways in Alzheimer's disease
(2006)
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Astrid Waltraud Bonert
- Alzheimer’s Disease (AD) is the most common neurodegenerative disorder marked by progressive loss of memory and cognitive ability. The pathology of AD is characterised by the presence of amyloid plaques, intracellular neurofibrillary tangles and pronounced cell death. The aim of this thesis was to investigate pathways involved in the Aß cascade of neurodegeneration. Since novel findings indicate that already this Aß species exerts neurotoxic effects long before hyperphosphorylated tau, neurofibrillary tangles and extracellular Aß plaques appear, the investigations were accomplished with specific regard to the effects of intracellular Aß. The Swedish double mutation in the APP gene results in six- to eightfold increased Aß production of both Aß1-40 and Aß1-42 compared to human wildtype APP cells (APPwt). Data obtained from PC12 cells indicate that it is possible to specifically increase the Aß load without enhancing APP expression levels. On the basis of these findings, it seemed possible to investigate dose-dependent effects of Aß in multiple experimental designs. These assay designs were created in order to mimick different in-vivo situations that are discussed to occur in AD patients: APPsw PC12 cells exhibit low physiological concentrations of Aß within picomolar range in contrast to APPsw HEK cells, expressing Aß levels within the nanomolar range. Of note, the APPsw HEK cells showed a specific and highly significant increase in the intracellular accumulation of insoluble Aß1-42. Moreover, an intracellular accumulation of Aß and APP was found in the mitochondria of the HEK APPsw cells suggesting a direct impact on mitochondrial function on these cells. This effect might finally lead to disturbances in the energy metabolism of the cell or to increased cell death. Furthermore, baseline g- and ß-secretase activity was assessed since these enzymes represent promising therapeutic targets to slow or halt the disease process. As expected, ß-secretase activity was significantly elevated in all APPsw cell lines. This might be due to the proximity of the Swedish double mutation next to the N-terminus of the Aß sequence. Interestingly, g-secretase activity was similarly increased in PC12 APPsw cells. In addition, the toxicity of different Aß species was investigated in SY5Y and PC12 cells with regard to their effect on cellular viability mirrored by mitochondrial activity using MTT assay. Here, it turned out that not monomers, but already dimers are neurotoxic correlates. Fibrillar Aß species showed the highest toxicity. In the next step, SY5Y cells forming endogenous, dimeric APP and Aß were investigated. In accordance with previous findings, these cells showed a decreased MTT reduction potential in comparison to APPwt and control SY5Y cells reflecting a decrease of cellular viability. The impaired energy metabolism of the cells was even more drastically mirrored by reduced baseline ATP levels. In the second part of this thesis, the expression and intracellular distribution of Bcl-2 family proteins and pro-apoptotic mitochondrial factors under baseline conditions and during oxidative stress were analyzed in the APPwt and APPsw bearing cells. The most prominent finding was the reduction of expression levels of the anti-apoptotic factor Bcl-xL in the cytosolic fractions of APPwt and APPsw PC12 cells. This might indicate that a lack of anti-apoptotic factors or their altered intracellular distribution, rather than an increase in caspase-dependent pro-apoptotic factors, could be responsible for the increased vulnerability of APPwt- and APPsw-transfected PC12 cells against oxidative stress. Since total Bcl-xL expression was unaffected in PC12 cells, in contrast to APPwt and APPsw-expressing SY5Y and HEK cells revealing significantly decreased Bcl-xL expression levels. Thus, alterations in Bcl-xL distribution seem to be an early event in the disease process. Increasing Bcl-xL expression might potentially be one promising strategy for AD modification. PC12 and HEK cells bearing APPsw or APPwt were treated with the potent g-secretase inhibitor DAPT. Of note, DAPT did not only efficiently block Aß production, but additionally led to an elevation of the MTT reduction potential, reflecting an increase in cellular viability. As another disease-modifying strategy, several efforts are undertaken to ameliorate AD-relevant symptoms by the treatment with nerve growth factor (NGF). Generally, it is known that substituted pyrimidines have modest growth-promoting effects. Here, KP544, a novel substituted pyrimidine, was characterised. This drug increased MTT reduction potential in terminally differentiated and undifferentiated PC12 cells. Furthermore, treatment with KP544 led to a reduction in Aß1-40 secretion. Thus, one may conclude that the target of KP544, GSK-3ß, represents a connecting link between the two main pathological hallmarks of AD and might thus be a very promising therapeutic target for AD.
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{5-[4'-(2,2,5,5-Tetramethyl-3-pyrroline-1-oxyl-3-carbonyl)biphenyl-4-ylethynyl]-2,3,7,8,12,13,17,18-octaethylporphyrinato}copper(II) benzene solvate : corrigendum
(2006)
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Michael Bolte
Jörn Plackmeyer
- In the paper by Bolte [Acta Cryst. (2006), E62, m1609-m1610], the chemical name in the title and the chemical diagram are incorrect. The correct title is {5-[4'-(2,2,5,5-Tetramethyl-3-pyrroline-1-oxyl-3-carbonyloxy)biphenyl-4-ylethynyl]-2,3,7,8,12,13,17,18-octaethylporphyrinato}copper(II) benzene solvate' and the correct diagram is given below.
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Zwischen Kulturindustrie und autonomer Kunst : das Subversive im Werk Bob Dylans
(2006)
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Axel Honneth
Richard Klein
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Zwei neue Käferarten aus dem mitteleuropäischen Faunengebiete
(1904)
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Joseph Breit
- Beschreibung der Arten: Trechus (Anophthalmus Strm.) vranensis n. sp. Lathrobium (Glyptomerus Müll.) Wingelmülleri n. sp.
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Zvi Keren: his contribution to Israel's music scene : an interview in honor of his 85th birthday
(2002)
- It is with great pride that I introduce a new section in this issue of Min-Ad: Israel Studies in Musicology, dedicated to interviews with musicians who have made major contributions to Israel’s music life. I am particularly pleased to inaugurate this section with an interview with our esteemed colleague (and in my case, teacher), Zvi Keren, a major figure in the development of Israel´s contemporary, jazz and light music. This interview is conducted by Alona Keren-Sagee, Zvi Keren´s daughter.
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Zosa Szjkowski and the Transfer of French-Jewish Archives to the US
(1999)
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Yoram Mayorek
