Year of publication
- Heavy ions and X-rays in brain tumor treatment : a comparison of their biological effects on tissue slice cultures (2009)
- Background: In this interdisciplinary project, the biological effects of heavy ions are compared to those of X-rays using tissue slice culture preparations from rodents and humans. Advantages of this biological model are the conservation of an organotypic environment and the independency from genetic immortalization strategies used to generate cell lines. Its open access allows easy treatment and observation via live-imaging microscopy. Materials and methods: Rat brains and human brain tumor tissue are cut into 300 micro m thick tissue slices. These slices are cultivated using a membrane-based culture system and kept in an incubator at 37°C until treatment. The slices are treated with X-rays at the radiation facility of the University Hospital in Frankfurt at doses of up to 40 Gy. The heavy ion irradiations were performed at the UNILAC facility at GSI with different ions of 11.4 A MeV and fluences ranging from 0.5–10 x 106 particles/cm². Using 3D-confocal microscopy, cell-death and immune cell activation of the irradiated slices are analyzed. Planning of the irradiation experiments is done with simulation programs developed at GSI and FIAS. Results: After receiving a single application of either X-rays or heavy ions, slices were kept in culture for up to 9d post irradiation. DNA damage was visualized using gamma H2AXstaining. Here, a dose-dependent increase and time-dependent decrease could clearly be observed for the X-ray irradiation. Slices irradiated with heavy ions showed less gamma H2AX-positive cells distributed evenly throughout the slice, even though particles were calculated to penetrate only 90–100 micro m into the slice. Conclusions: Single irradiations of brain tissue, even at high doses of 40 Gy, will result neither in tissue damage visible on a macroscopic level nor necrosis. This is in line with the view that the brain is highly radio-resistant. However, DNA damage can be detected very well in tissue slices using gamma H2AX-immuno staining. Thus, slice cultures are an excellent tool to study radiation-induced damage and repair mechanisms in living tissues.
- Collapse of flow: probing the order of the phase transition (2007)
- We discuss the present collective flow signals for the phase transition to the quark-gluon plasma (QGP) and the collective flow as a barometer for the equation of state (EoS). We emphasize the importance of the flow excitation function from 1 to 50A GeV: here the hydrodynamicmodel has predicted the collapse of the v1-flow at ~ 10A GeV and of the v2-flow at ~ 40A GeV. In the latter case, this has recently been observed by the NA49 collaboration. Since hadronic rescattering models predict much larger flow than observed at this energy, we interpret this observation as potential evidence for a first order phase transition at high baryon density pB.
- Longitudinal fluid-dynamics for ultrarelativistic heavy-ion collisions (2006)
- We develop a 1+1 dimensional hydrodynamical model for central heavy-ion collisions at ultrarelativistic energies. Deviations from Bjorken's scaling are taken into account by implementing finite-size profiles for the initial energy density. The calculated rapidity distributions of pions, kaons and antiprotons in central Au+Au collisions at the c.m. energy 200 AGeV are compared with experimental data of the BRAHMS Collaboration. The sensitivity of the results to the choice of the equation of state, the parameters of initial state and the freeze-out conditions is investigated. The best fit of experimental data is obtained for a soft equation of state and Gaussian-like initial profiles of the energy density.
- Signatures for black hole production from hadronic observables at the Large Hadron Collider (2006)
- The concept of Large Extra Dimensions (LED) provides a way of solving the Hierarchy Problem which concerns the weakness of gravity compared with the strong and electro-weak forces. A consequence of LED is that miniature Black Holes (mini-BHs) may be produced at the Large Hadron Collider in p+p collisions. The present work uses the CHARYBDIS mini-BH generator code to simulate the hadronic signal which might be expected in a mid-rapidity particle tracking detector from the decay of these exotic objects if indeed they are produced. An estimate is also given for Pb+Pb collisions.
- Nuclear equation of state from the nonlinear relativistic mean field theory (1988)
- The properties of symmetric nuclear matter are investigated in the nonlinear relativistic mean field theory of nuclear matter. We consider the constraints imposed by four nuclear ground state properties on the coupling constants and on the equation of state at zero and at finite temperature. We find that the compression constant K(ρ0) as well as the temperature is irrelevant for the stiffness of the equation of state for m*(ρ0)≤0.7. The main point is that the relativistic mean field theory exhibits acausal and unphysical behavior for compressibilities below K(ρ0)=200 MeV. Every set of coupling constants with a negative quartic coupling constant c is unstable against small quantum fluctuations.
- Separation of strangeness from antistrangeness in the phase transition from quark to hadron matter: Possible formation of strange quark matter in heavy-ion collisions (1987)
- We present a mechanism for the separation of strangeness from antistrangeness in the deconfinement transition. For a net strangeness of zero in the total system, the population of s quarks is greatly enriched in the quark-gluon plasma, while the s¯ quarks drift into the hadronic phase. This separation could result in ‘‘strangelet’’ formation, i.e., metastable blobs of strange-quark matter, which could serve as a unique signature for quark-gluon plasma formation in heavy-ion collisions. PACS: 25.70.Np, 12.38.Mh
- K/pi ratios in relativistic nuclear collisions : a signature for the quark-gluon plasma? (1989)
- Collisions of Si(14.5A GeV+Au are investigated in the relativistic-quantum-molecular-dynamics approach. The calculated pseudorapidity distributions for central collisions compare well with recent experimental data, indicating a large degree of nuclear stopping and thermalization. Nevertheless, nonequilibrium effects play an important role in such complex multihadron reactions: They lead to a strong enhancement of the total kaon production cross sections, in good agreement with the experimental data, without requiring the formation of a deconfined quark-gluon plasma.
- Possibility of detecting density isomers in high-density nuclear mach shock waves (1976)
- Up to now no experimentally feasible method for detecting abnormal nuclear states has been known. We propose to observe them in high-energy heavy-ion collisions through the disappearance of, or irregularities in, high-density nuclear Mach shock phenomena.
- Comment on "Exactly central heavy-ion collisions by nuclear hydrodynamics" (1981)
- Problems arising in viscous nuclear fluid dynamical models of high-energy heavy-ion collisions are discussed. The importance of an accurate treatment of the transport properties of the hot and dense nuclear matter is pointed out.
- Importance of nuclear viscosity and thermal conductivity and the analysis of the bounce-off effect in high energy heavy ion collisions (1981)
- We present an analysis of high energy heavy ion collisions at intermediate impact parameters, using a two-dimensional fluid-dynamical model including shear and bulk viscosity, heat conduction, a realistic treatment of the nuclear binding, and an analysis of the final thermal emission of free nucleons. We find large collective momentum transfer to projectile and target residues (the highly inelastic bounce-off effect) and explosion of the hot compressed shock zones formed during the impact. As the calculated azimuthal dependence of energy spectra and angular distributions of emitted nucleons depends strongly on the coefficients of viscosity and thermal conductivity, future exclusive measurements may allow for an experimental determination of these transport coefficients. The importance of 4π measurements with full azimuthal information is pointed out.