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Sumpflöwenzähne (Taraxacum sect. Palustria) in Hessen
(2007)
- 7 Sumpflöwenzahn-Arten sind in Hessen nachgewiesen, wobei von Taraxacum bavaricum und T. pauckertianum nur historische Nachweise vorliegen. Taraxacum hollandicum ist am weitesten in Hessen verbreitet und konnte bei der zwischen 2002 und 2004 durchgeführten Untersuchung in 10 von 12 untersuchten Gebieten mit mehr als 35000 Exemplaren nachgewiesen werden. Taraxacum germanicum wurde bei Münzenberg, Selters und im Mönchbruch gefunden. Taraxacum multilepis und T. trilobifolium haben individuenarme Populationen im Naturschutzgebiet Ludwigsquelle beziehungsweise im Mönchbruch, auf der Rodwiese und bei Bieber. Taraxacum subalpinum ist mit 2 sehr kleinen Populationen in der Wieseckaue bei Gießen die seltenste hessische Sumpflöwenzahnart.
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Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer
(2008)
- Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours. The over-expression of these proteins and their known functions in malignant neoplasms has led to the development of HDAC inhibitors (HDI) as new anti-neoplastic drugs. However, little is known about HDAC expression in renal cell cancer. Methods We investigated the expression of HDAC 1, 2 and 3 in 106 renal cell carcinomas and corresponding normal renal tissue by immunohistochemistry on tissue micro arrays and correlated expression data with clinico-pathological parameters including patient survival. Results Almost 60% of renal cell carcinomas expressed the HDAC isoforms 1 and 2. In contrast, HDAC 3 was only detected in 13% of all renal tumours, with particular low expression rates in the clear cell subtype. HDAC 3 was significantly higher expressed in pT1/2 tumours in comparison to pT3/4 tumours. Expression of class I HDAC isoforms correlated with each other and with the proliferative activity of the tumours. We found no prognostic value of the expression of any of the HDAC isoforms in this tumour entity. Conclusion Class I HDAC isoforms 1 and 2 are highly expressed in renal cell cancer, while HDAC 3 shows low, histology dependent expression rates. These unexpected differences in the expression patterns suggests alternative regulatory mechanisms of class I HDACs in renal cell cancer and should be taken into account when trials with isoform selective HDI are being planned. Whether HDAC expression in renal cancers is predictive of responsiveness for HDI will have to be tested in further studies.
