Year of publication
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- Equation of state, spectra and composition of hot and dense infinite hadronic matter in a microscopic transport model (1998)
- Equilibrium properties of infinite relativistic hadron matter are investigated using the Ultrarelativistic Quantum Molecular Dynamics (UrQMD) model. The simulations are performed in a box with periodic boundary conditions. Equilibration times depend critically on energy and baryon densities. Energy spectra of various hadronic species are shown to be isotropic and consistent with a single temperature in equilibrium. The variation of energy density versus temperature shows a Hagedorn-like behavior with a limiting temperature of 130 +/- 10 MeV. Comparison of abundances of different particle species to ideal hadron gas model predictions show good agreement only if detailed balance is implemented for all channels. At low energy densities, high mass resonances are not relevant; however, their importance raises with increasing energy density. The relevance of these different conceptual frameworks for any interpretation of experimental data is questioned.
- Microscopic analysis of thermodynamic parameters from 160 MeV/n - 160 GeV/n (1997)
- Microscopic calculations of central collisions between heavy nuclei are used to study fragment production and the creation of collective flow. It is shown that the final phase space distributions are compatible with the expectations from a thermally equilibrated source, which in addition exhibits a collective transverse expansion. However, the microscopic analyses of the transient states in the reaction stages of highest density and during the expansion show that the system does not reach global equilibrium. Even if a considerable amount of equilibration is assumed, the connection of the measurable final state to the macroscopic parameters, e.g. the temperature, of the transient ''equilibrium'' state remains ambiguous.
- Are we close to the QGP? - Hadrochemical vs. microscopic analysis of particle production in ultrarelativistic heavy ion collisions (1997)
- Ratios of hadronic abundances are analyzed for pp and nucleus-nucleus collisions at sqrt(s)=20 GeV using the microscopic transport model UrQMD. Secondary interactions significantly change the primordial hadronic cocktail of the system. A comparison to data shows a strong dependence on rapidity. Without assuming thermal and chemical equilibrium, predicted hadron yields and ratios agree with many of the data, the few observed discrepancies are discussed.
- Microscopic models for ultrarelativistic heavy ion collisions (1998)
- In this paper, the concepts of microscopic transport theory are introduced and the features and shortcomings of the most commonly used ansatzes are discussed. In particular, the Ultrarelativistic Quantum Molecular Dynamics (UrQMD) transport model is described in great detail. Based on the same principles as QMD and RQMD, it incorporates a vastly extended collision term with full baryon-antibaryon symmetry, 55 baryon and 32 meson species. Isospin is explicitly treated for all hadrons. The range of applicability stretches from E lab < 100$ MeV/nucleon up to E lab> 200$ GeV/nucleon, allowing for a consistent calculation of excitation functions from the intermediate energy domain up to ultrarelativistic energies. The main physics topics under discussion are stopping, particle production and collective flow.
- Local equilibrium in heavy-ion collisions: microscopic analysis of a central cell versus infinite matter (2000)
- REVTEX, 27 pages incl. 10 figures and 3 tables; Phys. Rev. C (in press) Journal-ref: Phys.Rev. C62 (2000) 064906. We study the local equilibrium in the central V = 125 fm3 cell in heavy-ion collisions at energies from 10.7 A GeV (AGS) to 160 A GeV (SPS) calculated in the microscopic transport model. In the present paper the hadron yields and energy spectra in the cell are compared with those of infinite nuclear matter, as calculated within the same model. The agreement between the spectra in the two systems is established for times t >= 10 fm/c in the central cell. The cell results do not deviate noticeably from the infinite matter calculations with rising incident energy, in contrast to the apparent discrepancy with predictions of the statistical model (SM) of an ideal hadron gas. The entropy of this state is found to be very close to the maximum entropy, while hadron abundances and energy spectra differ significantly from those of the SM.
- Nonequilibrium models of relativistic heavy-ion collisions (2004)
- To be published in J. Phys. G - Proceedings of SQM 2004 : We review the results from the various hydrodynamical and transport models on the collective flow observables from AGS to RHIC energies. A critical discussion of the present status of the CERN experiments on hadron collective flow is given. We emphasize the importance of the flow excitation function from 1 to 50 A.GeV: here the hydrodynamic model has predicted the collapse of the v2-flow ~ 10 A.GeV; at 40 A.GeV it has been recently observed by the NA49 collaboration. Since hadronic rescattering models predict much larger flow than observed at this energy we interpret this observation as evidence for a first order phase transition at high baryon density r b. Moreover, the connection of the elliptic flow v2 to jet suppression is examined. It is proven experimentally that the collective flow is not faked by minijet fragmentation. Additionally, detailed transport studies show that the away-side jet suppression can only partially (< 50%) be due to hadronic rescattering. Furthermore, the change in sign of v1, v2 closer to beam rapidity is related to the occurence of a high density first order phase transition in the RHIC data at 62.5, 130 and 200 A.GeV.
- Strangeness dynamics and transverse pressure in relativistic nucleus-nucleus collisions (2004)
- We investigate hadron production as well as transverse hadron spectra from proton-proton, proton-nucleus and nucleus-nucleus collisions from 2 A·GeV to 21.3 A·TeV within two independent transport approaches (HSD and UrQMD) that are based on quark, diquark, string and hadronic degrees of freedom. The comparison to experimental data on transverse mass spectra from pp, pA and C+C (or Si+Si) reactions shows the reliability of the transport models for light systems. For central Au+Au (Pb+Pb) collisions at bombarding energies above ~5 A·GeV, furthermore, the measured K± transverse mass spectra have a larger inverse slope parameter than expected from the default calculations. We investigate various scenarios to explore their potential effects on the K± spectra. In particular the initial state Cronin effect is found to play a substantial role at top SPS and RHIC energies. However, the maximum in the K+/..+ ratio at 20 to 30 A·GeV is missed by 40% and the approximately constant slope of the K± spectra at SPS energies is not reproduced either. Our systematic analysis suggests that the additional pressure - as expected from lattice QCD calculations at finite quark chemical potential µq and temperature T- should be generated by strong interactions in the early pre-hadronic/partonic phase of central Au+Au (Pb+Pb) collisions.
- Review of QGP signatures - ideas versus observables (2004)
- We investigate hadron production and transverse hadron spectra in nucleus-nucleus collisions from 2 A·GeV to 21.3 A·TeV within two independent transport approaches (UrQMD and HSD) based on quark, diquark, string and hadronic degrees of freedom. The enhancement of pion production in central Au+Au (Pb+Pb) collisions relative to scaled pp collisions (the ’kink’) is described well by both approaches without involving a phase transition. However, the maximum in the K+ p+ ratio at 20 to 30 A·GeV (the ’horn’) is missed by ~ 40%. Also, at energies above ~5 A·GeV, the measured K± mT-spectra have a larger inverse slope than expected from the models. Thus the pressure generated by hadronic interactions in the transport models at high energies is too low. This finding suggests that the additional pressure - as expected from lattice QCD at finite quark chemical potential and temperature - might be generated by strong interactions in the early pre-hadronic/partonic phase of central heavy-ion collisions. Finally, we discuss the emergence of density perturbations in a first-order phase transition and why they might affect relative hadron multiplicities, collective flow, and hadron mean-free paths at decoupling. A minimum in the collective flow v2 excitation function was discovered experimentally at 40 A·GeV - such a behavior has been predicted long ago as signature for a first order phase transition.
- Nanolesions induced by heavy ions in human tissues: experimental and theoretical studies (2012)
- The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation. The cascade of events leading to cell death or late effects starts from stochastic energy deposition on the nanometer scale and the corresponding lesions in biological molecules, primarily DNA. We have developed experimental techniques to visualize DNA nanolesions induced by heavy ions. Nanolesions appear in cells as “streaks” which can be visualized by using different DNA repair markers. We have studied the kinetics of repair of these “streaks” also with respect to the chromatin conformation. Initial steps in the modeling of the energy deposition patterns at the micrometer and nanometer scale were made with MCHIT and TRAX models, respectively.
- In Silico Analysis of Cell Cycle Synchronisation Effects in Radiotherapy of Tumour Spheroids (2013)
- Abstract: Tumour cells show a varying susceptibility to radiation damage as a function of the current cell cycle phase. While this sensitivity is averaged out in an unperturbed tumour due to unsynchronised cell cycle progression, external stimuli such as radiation or drug doses can induce a resynchronisation of the cell cycle and consequently induce a collective development of radiosensitivity in tumours. Although this effect has been regularly described in experiments it is currently not exploited in clinical practice and thus a large potential for optimisation is missed. We present an agent-based model for three-dimensional tumour spheroid growth which has been combined with an irradiation damage and kinetics model. We predict the dynamic response of the overall tumour radiosensitivity to delivered radiation doses and describe corresponding time windows of increased or decreased radiation sensitivity. The degree of cell cycle resynchronisation in response to radiation delivery was identified as a main determinant of the transient periods of low and high radiosensitivity enhancement. A range of selected clinical fractionation schemes is examined and new triggered schedules are tested which aim to maximise the effect of the radiation-induced sensitivity enhancement. We find that the cell cycle resynchronisation can yield a strong increase in therapy effectiveness, if employed correctly. While the individual timing of sensitive periods will depend on the exact cell and radiation types, enhancement is a universal effect which is present in every tumour and accordingly should be the target of experimental investigation. Experimental observables which can be assessed non-invasively and with high spatio-temporal resolution have to be connected to the radiosensitivity enhancement in order to allow for a possible tumour-specific design of highly efficient treatment schedules based on induced cell cycle synchronisation. Author Summary: The sensitivity of a cell to a dose of radiation is largely affected by its current position within the cell cycle. While under normal circumstances progression through the cell cycle will be asynchronous in a tumour mass, external influences such as chemo- or radiotherapy can induce a synchronisation. Such a common progression of the inner clock of the cancer cells results in the critical dependence on the effectiveness of any drug or radiation dose on a suitable timing for its administration. We analyse the exact evolution of the radiosensitivity of a sample tumour spheroid in a computer model, which enables us to predict time windows of decreased or increased radiosensitivity. Fractionated radiotherapy schedules can be tailored in order to avoid periods of high resistance and exploit the induced radiosensitivity for an increase in therapy efficiency. We show that the cell cycle effects can drastically alter the outcome of fractionated irradiation schedules in a spheroid cell system. By using the correct observables and continuous monitoring, the cell cycle sensitivity effects have the potential to be integrated into treatment planing of the future and thus to be employed for a better outcome in clinical cancer therapies.