Universitätspublikationen
776 search hits
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Studium im Ausland : Informationen und praktische Hinweise
(2005)
- Informationsbroschüre des International Office der Johann Wolfgang Goethe-Universität Frankfurt am Main
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Protein C preserves microcirculation in a model of neonatal septic shock
(2005)
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Doris Fischer
Marcel Friedrich Nold
Claudia A. Nold-Petry
Antonio Furlan
Alex Veldman
- Objectives: Sepsis remains a disease with a high mortality in neonates. Microcirculatory impairment plays a pivotal role in the development of multiorgan failure in septic newborns. The hemodynamic effects of recombinant activated protein C (rhAPC) were tested in an animal model of neonatal septic shock focusing on intestinal microcirculation.
Materials and methods: Endotoxic shock was triggered by intravenous application of Escherichia coli lipopolysaccarides in newborn piglets. Thereafter, five animals received a continuous infusion of 24 µg/kg/h rhAPC, and five received vehicle for control. Over the course of three hours, intestinal microcirculation was assessed by intravital microscopy every 30 min. Macrocirculation and blood counts were monitored simultaneously.
Results: After a short hypotensive period in all animals, the arterial blood pressure returned to baseline in the rhAPC-treated piglets, whereas the hypotension became increasingly severe in the controls. By 90 min, mean blood pressure in the controls was significantly lower than in the treatment group. Similar observations were made regaring microcirculation. After an early impairment in all study animals, functional capillary density and intestinal microcirculatory red blood cell velocity and red blood cell flow recovered in the rhAPC group, but deteriorated further in the control piglets.
Conclusion: Recombinant activated protein C protects macro- and microcirculation from endotoxic shock.
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JFR-Newsletter : Publikationsorgan des Jungen Forums Rechtsphilosophie (JFR) ; Nr. 1/2005
(2005)
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JFR-Newsletter : Publikationsorgan des Jungen Forums Rechtsphilosophie (JFR) ; Nr. 2/2005
(2005)
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kurz und kn@pp news : Nr. 1
(2005)
- Erste Ausgabe des Instituts-Newsletters
* Depression: Neue Strategien für Hausarztpraxis
* Link des Monats: Jeder Fehler zählt
* E-Learning: Aktueller Stand und Chancen
* Neue Lehrpraxen für das Blockpraktikum Allgemeinmedizin
* Qualitätsförderung und Patientensicherheit
* Neues Hausarztmodell vereinbart
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kurz und kn@pp news : Nr. 2
(2005)
- * Antrittsvorlesung zog zahlreiche Zuhörer an
* Fehlerberichtssystem mit dem Richard-Merten-Preis ausgezeichnet
* Zentrum für Gesundheitswissenschaften gegründet
* Die Zukunft ist chronisch...
* PRoMPT-Projekt hat begonnen – Mehr als 70 Praxisteams geschult
* Symposium E-Learning – Innovation für die medizinische Lehre
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kurz und kn@pp news : Nr. 3
(2005)
- * „Den Patienten im Blick behalten“ - Konferenz zum Thema Chronic Care in der Primärmedizin
* Richard-Merten-Preis 2005 Fehlerberichts- und Lernsystem für Hausärzte ausgezeichnet
* Ab 2006 Praktisches Jahr in allgemeinmedizinischen Lehrpraxen
* Der Arbeitsbereich Lehre stellt sich vor
* Neue Leitlinie Herzinsuffizienz: Machen Sie mit beim Praxistest!
* Vermeidung von Medikationsfehlern in der Hausarztpraxis
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Tätigkeitsbericht WS 04/05 bis WS 05/06 / Interdisziplinäres Zentrum für Ostasienstudien IZO i.G.
(2005)
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The QCD phase diagram at zero and small baryon density
(2005)
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Owe Philipsen
- I review recent developments in determining the QCD phase diagram by means of lattice simulations.
Since the invention of methods to side-step the sign problem a few years ago, a number
of additional variants have been proposed, and progress has been made towards understanding
some of the systematics involved. All available techniques agree on the transition temperature
as a function of density in the regime mq/T <~1. There are by now four calculations with signals
for a critical point, two of them at similar parameter values and with consistent results. However,
it also emerges that the location of the critical point is exceedingly quark mass sensitive. At the
same time sizeable finite volume, cut-off and step size effects have been uncovered, demanding
additional investigations with exact algorithms on larger and finer lattices before quantitative conclusions
can be drawn. Depending on the sign of these corrections, there is ample room for the
eventual phase diagram to look as expected or also quite different, with no critical point at all.
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Newsletter des Fachbereichs Rechtswissenschaft Johann Wolfgang Goethe-Universität Frankfurt am Main : Ausgabe Sommersemester 2005
(2005)
